Soy isoflavones not A risk for breast cancer survivors

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Soy food consumption does not increase the risk of cancer recurrence or death survivors of breast cancer, according to the results of a study on the AACR Annual meeting 2011, instead of April is 2-6 presented.

Researchers the association between soya food intake and breast cancer studied for cancer results survivors, using data from a multi-institution collaborative study, that breast cancer pooling project.

"There has been concern about the safety of soy foods for women with breast cancer," Epidemiology Center, Vanderbilt University Medical Center said lead researcher Xiao OU Shu, m.d., PhD., Professor of medicine at the Vanderbilt. "Soy foods contain large amounts of isoflavones, which are known to bind to estrogen receptors and estrogen-like and estrogen-active impact." There are fears that isoflavones may increase the risk of recurrence in patients with breast cancer, because it low estrogen levels as a result of the treatment of cancer. "We are very concerned that isoflavones may endanger the effects of tamoxifen on breast cancer, since both tamoxifen and isoflavones bind to estrogen receptors."

This research was by the American recovery and Reinvestment Act of 2009, which combined financed the resources of the four National Cancer Institute funded studies: the Shanghai breast cancer survival study; Life after cancer epidemiology study; the women's healthy food and life study; and the nurses' health study. These cohorts include together 18,312 women between 20 and 83 years, who had invasive primary breast cancer.

Soy isoflavones was recording for 16,048 of women an average of 13 months evaluated according to the food frequency questionnaires for a group of soy isoflavones in three cohorts with breast cancer diagnosis and tofu and soy milk consumption in a cohort. Breast cancer results were, judged on average, nine years after the cancer diagnosis.

Results of one of the survivors who consumed the highest amounts of soy isoflavones (more than 23 mg per day) were the results of this compared with intakes of lowest (0.48 mg per day or lower). The average daily soy isoflavones recording under U.S. women was 3.2 mg; However, the amount in the Shanghai Group was significantly higher at 45.9 mg.

Women in the highest category inclusion of more than 23 mg / day had a 9 percent reduced risk of mortality and one 15 percent reduced risk for recurrence, compared to those taking the lowest had. However these results not achieved, what the scientists call statistical significance, suggested that the statement could be chance.

"Our results show that it helpful can be included for women as part of a healthy diet, soy foods, even if they have breast cancer,", said Shu. "This may not directly generalized additions to soy, however, as supplements of soy products in the types and quantities of isoflavones can be different."Further analysis of the data from this study, education the interaction of soy isoflavones and tamoxifen, is presented at the AACR Annual meeting.

Source:
American Association for cancer research (AACR)