NYU Langone Medical Center cardiologists present to ACC 60th of annual scientific meeting

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Cardiologists from the heart & vascular a re Institute at NYU Langone Medical Center presents new research at the American College of Cardiology 60th of annual scientific meeting instead of April 2-5, 2011 in New Orleans, Louisiana. Significant research results presented by NYU Langone cardiologists included:

The relationship between bleeding and mortality in patients on dual antiplatelet therapy vs. aspirin alone: results from the study of CHARISMA

Author: Jeffrey S. Berger, MD, MS, FACC, Assistant Professor, medicine, and Director of the heart vascular thrombosis

Is little known about the association between bleeding and death and the actual cause of death in patients under different antiplatelet agents. Researchers examined the association between bleeding and mortality to assess whether this mapping in patients on dual antiplatelet therapy (DAPT) compared to aspirin alone is different to. Researchers examined the association between moderate or severe bleeding and all cause, cardiovascular and cancer mortality in 15,603 patients with cardiovascular disease or multiple risk factors in the Clopidogrel for high atherothrombotischer risk and ischemic stabilization, management and prevention trial (CHARISMA) enrolled. The study shows patients with moderate or a higher incidence of all cause, cardiovascular and cancer mortality had severe bleeding. After split adjustment mortality, but also cancer mortality remained moderate/severe bleeding independently associated with not only all cause. It was a significant interaction between bleeding and effectiveness of antiplatelet therapy for all cause, cardiovascular, and cancer mortality. All cause, cardiovascular, and cancer mortality was mapped in subjects on aspirin alone therapy moderate/severe bleeding but not to topics on dual antiplatelet. The study shows in stable patients, a significantly increased risk of all cause, cardiovascular and cancer mortality is a moderate or severe bleeding. This risk but differed in patients taking aspirin versus dual antiplatelet therapy alone.

Abstract 1101-142: Monday, April 4, 2011

Six year results with DES, BMS or medical therapy in the oats study treated patients

Principal investigator: Judith S. Hochman, MD, Harold Snyder family Professor of Cardiology and Director, cardiovascular clinical research

The closed trial (Oct) artery percutaneous coronary interventions (PCI) or optimal medical therapy (MED) alone for the treatment of a completely closed artery is a randomized study routine infarction associated with 3 to 28 days after myocardial infarction in people who met with high risk criterion. The study showed a difference in the death Reinfarction and heart failure between study groups mean follow up of 6 years. Although the majority of percutaneous coronary intervention treated patients in the study with bare metal stents (BMS), also drug were implanted in the second half of the study eluting stents (DES). Researchers carried out an exploratory analysis of the long-term desired results for drug eluting stents deployment versus bare metal stents the occlusion of goal in the Group of percutaneous coronary intervention vs. medical therapy in the Oct process. You compared the clinical results of percutaneous coronary intervention patients with drug eluting stents, bare metal stents and medical therapies (of n = 79, BMS n = 393, 552 = MED n) up to 6 years (mean survivor follow up 5.1 years) a maximum follow-up. In the analysis of occurrence of death, Reinfarction and class IV was heart failure the 6 year similar (20.4% of the DES, 18.9% of the BMS and 18.4% Med). While the follow-up developed, 33.4% of the DES and 44.4% of the BMS 48.1% of MED patients angina. The rate of Revascularization during follow-up was 11.3% in the DES, 20.5% of the BMS and 22.5%. There is no long-term risk of death, Reinfarction or class IV heart failure with drug eluting stent use when compared to bare metal stents or reduced medical treatment alone. The study suggests an association between drug eluting stents and freedom from angina pectoris and Revascularization relative to the medical therapy. Researchers stress, only interpret the data due to the small number of patients is treated with drug eluting stents and the non-randomized nature of the analysis.

Abstract number 2508-532: Monday, April 4, 2011

Platelet size is an excellent substitute for platelets activity

Authors: Michael Merolla, medicine; Michael A. Nardi, MS, Associate Professor, Pediatrics; Liang Hu, Hematology; Caron B. Rockman, MD, Associate Professor, surgery; Jeffrey S. Berger, MD, MS, FACC, Assistant Professor, medicine, and Director of the heart vascular thrombosis

Increased platelet activity associated with an increased risk of cardiovascular morbidity and mortality. A variety of techniques in laboratory research and clinical practice used measure platelet activity, but there is no accepted gold standard. Mean platelet volume (MPV) is easy than part of the routine clinical laboratory tests. It is fast and inexpensive. Researchers platelet volume with other measurements of the platelet activity examined the Association the medium. 154 Patients with and without vascular disease for analysis were recruited in the study. In addition to the measurement of mean platelet volume, platelet count researchers measured, immature platelet fraction, reticulated percent platelets, PAC-1 platelet marker stain and impedance Aggregometry. The study shows my Platelet volume with several markers platelet activity of serum markers for an increased platelet turnover is connected. Future studies should examine whether medium-sized platelet reached as part could routine of laboratory tests identify volume patients at risk for heart and cardiovascular events and help guide anti-platelet and other pharmacological strategies of risk factor.

Abstract 1146-95: Tuesday, April 5, 2011

Source:
Lauren Woods
NYU Langone Medical Center / New York University School of medicine