He sniffing leukemia by dogs in people

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Researchers at North Carolina State University are looking for in non-Hodgkin's lymphoma - genes involved narrowing, by dogs in people.

People and dogs not only parts camaraderie and living room, and it is also a similar genetic makeup. In addition they have the same types of cancer including lymphoma together. Used Lymphoma because purebred dogs of the same breed less genetic variation among them have facilitated it as Dr. Matthew Breen, Professor of genomics at NC State, do canines as a genetic model for the study to identify areas on canine chromosomes, which can be involved with cancer.

In a paper published in the journal leukemia and Lymphoma of Breen's team took the genetic information of dogs with non-Hodgkin's lymphoma, and then rearranged or "new" the genome of the dogs so that genomically speak, they were human. The researchers then compared the collected canine genome with which the people with non-Lymphoma of Hodgkin's, to see which chromosomes with the cancer in humans and canines were involved.

"This is the first time, that we have this information from dogs compared to Lymphoma directly with existing data from human patients appropriate cancer diagnosed and use the same technique," Dr. Rachael Thomas, Assistant Professor of Molecular Biomedical says Sciences at NC State research and lead author of the paper.

The data showed that there were only a few genes with lymphoma, shared by people and dogs. This is in contrast to current research into human Lymphoma, where numerous genes have been identified as possibly a relationship to the cancer. Breen and his colleagues hope that this data will show the most likely culprits of genetic researchers in direction.

"In essence we removed the background noise from the human data," Breen says. "Lymphoma of Genomics is much more complex in human patients as in dog patients." This study tells us, while both people? and dogs? have comparable disease clinical and cellular level that are associated with genetic changes to the same types of cancer much less complex in the dog. This suggests that perhaps there is a lot of genetic noise in human cancers, which are not essential components of the process. "While the human studies are looking for in numerous places in the genome, we need to focus the dog data show is what divided, and they are very few regions."

The study was funded by the national institutes of health and the American Kennel Club Canine Health Foundation. The Department Molecular Biomedical Sciences is part of the NC State College of veterinary medicine.

Note

Processing canine tumor-associated aneuploidy by 'genomic recoding' recurrent DNA copy number aberrations in 150 non-Hodgkin's lymphoma

Authors: Rachael Thomas, Alison Motsinger-Reif, Matthew Breen, et al, NC State University published: leukemia & Lymphoma, 2011

Abstract:

Identification of non-Hodgkin's Lymphoma (NHL) pathogenesis is most intimately associated with genomic regions by the genetic heterogeneity of the populations confounded. We suspect that the combined limited genetic variation of pure-bred dogs, with the contrasting architecture of human and canine karyotype, which will increase the basic NHL-related chromosome aberrations in both penetrance. We respondents not random aneuploidy in 150 canine NHL reveals limited genomic instability in comparison to their human counterparts and no evidence of CDKN2A/B delete in canine B-cell NHL. Format ' genomic recoding ' canine NHL data in a "virtual"human chromosome showed remarkably some regions copy number aberration (CNA) divided between the two regions dog species, limited chromosomes 13 and 31, and human chromosomes 8 and 21. Our data suggest that gene discovery in NHL use comparative studies the less complex association between CNAs and tumor pathogenesis canine patients can be improved.

Source:
North Carolina State University