Dr. Tong Chen presented the findings at a press conference at 8 am on 6 April at the American Association for cancer research (AACR) 102nd 2011 is meeting in Orlando, Florida the study first common Ohio State cancer clinical trial in China are carried out.
"We conclude from this study, that treatment is six months of the strawberry safe and easy to consume." In addition our preliminary data suggests that histological grade reduces strawberries precancerous lesions and cancer molecular events, "said Chen, lead author and Assistant Professor in the Department of medical oncology, Department of internal medicine at Ohio State." It is also a member of molecular carcinogenesis and Chemoprevention program in Ohio State's comprehensive cancer center.
Previously published research by Chen and colleagues found that freeze-dried strawberries tumor development in the esophagus of rats significantly inhibited. Based on these results, a phase began the researchers IB study in China, to study the impact of the freeze-dried strawberries on patients with esophageal precancerous lesions.
"We found that daily consumption of strawberries in esophageal carcinogenesis, including cell proliferation, inflammation and gene suppresses transcription, various biomarkers," Chen said.
Each of the 36 participants ate 60 grams (about two ounces) of freeze-dried strawberries daily for six months. The researchers obtain biopsy samples before and after the strawberry consumption. The results showed that 29 of 36 participants experienced a decline in the histological grade of precancerous lesions during the study.
"We predict that the majority of patients with precancerous lesions in their esophagus cancer will develop in later decades", said Chen. "Our study is important because it shows that strawberries can slow down the progression of precancerous lesions in the esophagus." Strawberries may be an alternative or together with other chemopreventive drugs, the cancer can work to prevent. "But we need to test this in randomized, placebo controlled studies in the future."
Esophageal cancer the third most common stomach cancers and the sixth most common cause of cancer death in the world, said Chen, who has a doctorate in health care. Chen and her team study Carcinoma, esophageal squamous cell that makes up 95% of cases of esophageal cancer worldwide. The survival of this type of esophageal cancer is very low, with only 10 percent of the patients life 5 years after diagnosis.
Esophageal squamous cell carcinoma is fairly common in China, Japan, the Transkei region of South Africa, Iran, France and Puerto Rico.
"Because this clinical study in China, have significantly more effort to set up and fill the trial than is typically required on our own institution." "Nevertheless, we a team of highly collaborative investigators have established that work well together", said Chen.
China has the largest population in the world, and the number of potential participants for clinical trials is higher than in any other country in the world.
"We believe that establishing collaborative research clinical research can improve team and our project is" open doors "for several other studies in China," Chen said.
In the United States, Canada, and Europe, the risk factors for the development of esophageal cancer include use of tobacco and alcohol, along with poor diet, fruit and vegetables are missing.
In Asia, additional risk factors include eating salty foods and foods with different mycotoxins, lack of dietary vitamins and minerals and thermal injuries caused by the consumption of hot beverages contaminated.
More than 16,000 esophageal cancer in the United States will be diagnosed this year according to the American Cancer Society.
Notes:
Financing of the California Strawberry Commission supported this research.
Other researchers of the study involved are Fei yan and Huaji Guan of Ohio State. Gary D. Stoner of the Medical College of Wisconsin; and from China: Jiaming Qian, Guiqi Wang, Ning Lu, Hongbing Zhang, Mingzhou Guo, Lian Li, Yanli Zeng, Xiaomin Wang.
Source:
Eileen Scahill
Ohio State University Medical Center
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