Researchers present new insights into cancer and gene therapy

DNA's role as a master blueprint of cell means that changes even small sequence can have disastrous consequences. Therefore comes to copy much of our understanding of cancer development from studying cells and DNA and repair sequence error - and how they can go processes wrong.

Next week will bring together a thematic programme in the American society for Biochemistry and molecular biology's annual meeting at experimental biology 2011 Conference in Washington, D.C., researchers from across the country, to discuss the latest developments in DNA replication, Recombination, and repair and the importance of these activities in cancer and gene therapy.

Topic organizers Marlene Belfort in the Wadsworth Center at the Department of health and JoAnn B. Sweasy from Yale University have New York State put together a roster of experts, which will be new discoveries such as cells manage the process of copying DNA, add and remove lines of sequence in the genome, and the consequences of the error occur.

Aberrant DNA repair and genomic instability and cancer: the first platform meeting will be held from 9:55 am to 12: 10 pm Sunday. Cells accumulate at least 20,000 DNA lesions a day required for the repair of still healthy cellular function. Because maintaining a stable genome is crucial for the prevention of diseases, research on aberrant DNA repair and other processes are, important aspects of the understanding of the development of cancer change the DNA sequence. In this session, researchers at the University of Texas MD Anderson Cancer Center, Yale University and the Massachusetts be Institute of technology function.

Site specific recombination in chromosome dynamics and gene therapy: the second round of talks, to from 3:45 pm to 6 pm on Mondays, instead focused on gene therapy, a promising area of research, developed the techniques to correct mutations as a means for the prevention or treatment of disease. The three conversations are researchers from the University of Texas at Austin, the University of Washington and the University of Pennsylvania, describes certain applications currently under study for targeted gene correction and genome Engineering function.

Replication of Noncanonical DNA sequences and genomic instability: the third meeting platform in the program, 9:55 am to 12:15 P.m. Tuesday, will highlight research on noncanonical or nonstandard, DNA structures, to destabilize the DNA strands and can lead to rupture and mutations. Structures present research about the effects of the non-canonical DNA mutation-causing this session and copy the mechanisms to avoid the cells with DNA and repair damage to mutations and cancer. Scientists from the Anderson Cancer Center are Robert Wood Johnson School of medicine, Yale University and the University of Texas m.d. speak.

Retro's in the genome plasticity and cancer: in the last round of talks, from 1:45 P.m. to 4 P.m. Wednesday, instead of three scientists talk about retro's, extends the genetic sequence, which can copy and paste the copy in different locations in the genome. Inserting retro item can produce different results, some favorable and some fatal, and this session covers both aspects. A researcher from the Cleveland Clinic describes his studies on a retrovirus, which can cause prostate cancer, and two scientists from the middle of Wadsworth talk about the Retrotransposons and contrasting capabilities in the genetic diversity and aging.

Source:
Federation of American societies for experimental biology (FASEB)
American society for Biochemistry and molecular biology