Called treasure these endings or tips, Telomeres, chromosomal damage and genomic instability that can lead to cancer and other diseases.
"We found a single-point variation in the genome strongly connected with a 19 percent decline in bladder cancer risk." The same variant is risk even with longer Telomeres, which accounts for a portion of the overall reduction in, linked "said author first Jian gu, PhD, Assistant Professor of MD Anderson's Department of epidemiology."
Telomere Length decreases with increasing age Gu said, and short Telomeres age-related diseases such as stroke, Alzheimer's disease, diabetes, are associated with cardiovascular disease and cancer.
Previous studies linked separately Telomere Length risk of cancer or genetic variation. The paper by Gu and colleagues is the first to connect the two.
"The understanding of complex genetic regulation of Telomere length and the relationship to the causes of the bubble and other types of cancer help reduce development of therapies and lifestyle changes to the risk of cancer," said senior author Xifeng Wu, m.d., PhD., Professor and head of MD Anderson's Department of epidemiology.
In 2003, Wu and colleagues were the first to show that short Telomeres of the risk of a bubble, lungs, kidneys and head and neck cancers in a human increase epidemiological study.
Start with 300,000 SNPs
The new findings were published research, an AACR Journal presented by Gu at the AACR Annual meeting and at the same time in cancer prevention.
AACR President Elizabeth Blackburn, PhD., the Morris heart stone Professor of biology and Physiology at the University of California San Francisco, won the Nobel Prize for Physiology or medicine for their role in the discovery of Telomeres and the enzyme telomerase in 2009. She wrote an editorial in cancer prevention research, and played with Gu at a press conference on Saturday to discuss the importance of the results of the study.
Researchers study first a genome-wide association identify genetic variations Telomeres associated with length. It analysed more than 300,000 single nucleotide polymorphisms (SNPs), common points of variation in the genome in 459 healthy control groups.
This narrows the field 15,120 SNPs, which were then validated in 1,160 healthy control groups in two independent populations. You chose the top four SNPs, with all three groups for the bladder cancer Association study of Telomere length were associated with.
Then there was a
The team assessed the Association of these four sites with the risk of bladder cancer in a case control study of 969 patients and 946 controls. Only one, a SNP on chromosome 14 known was associated with rs398652, bladder cancer risk.
Since the SNP both Telomere length and bladder cancer risk associated with, the team conducted a mediation analysis to determine whether length some of the risks causing the affect of the Telomeres. Telomere length was 14 percent the SNP effects on bladder cancer.
"We think that remaining part of the effect can be caused by inflammation or immunity SNP on bladder cancer," Gu said. "But understanding the rest of risk require more fundamental research." Rs398652, closest to a gene on chromosome 14 is called PELI2, which is involved in the inflammatory and immune response.
Follow up studies focus on whether this SNP said other types of cancer, particularly affected Telomere length as lung, kidney and esophageal cancer, Gu, as also the biological mechanisms that the SNP Telomere Length affects on associated with.
Notes:
Scholarships of the National Cancer Institute funded this research.
Co-authors with gu and Wu are lead co-author Meng Chen, PhD., Sanjay Shete, PhD., Christopher Amos, PhD., Yuanqing ye, PhD., and Jie Lin, PhD., all Department of epidemiology, and Ashish Kamat, m.d., and Colin Dinney, MD, the MD Anderson's Department of Urology.
Source:
Scott MERVILLE
University of Texas M. D. Anderson Cancer Center
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